We flew into Vegas to drive to the Grand Canyon, then drove back to Vegas for one night there and to catch our flight out.
We hired a car at the airport. Note that the hire car garage is off site, and you have to take a shuttle bus from the airport. Once we were out of the garage, it was quite easy to navigate our way to the freeway. This was our first time driving in the US, and we both found it a bit exhausting. I think we did at least 3 driver swaps. We stopped just outside Vegas for a bite to eat, briefly at Hoover Dam just to take some photos, and then again at a cute little museum/gift shop/information centre in a little Route 66 town called Ash Fork. It took us about 5 hours to complete the drive, and we arrived at the GC just before sunset.
We also stayed at Bright Angel Lodge, and thought it was fantastic! We did the overnight mule ride, which left from just near Bright Angel Lodge, so it was very convenient. We were there 3 nights in total, including the night we spent at Phantom Ranch (at the bottom of the canyon), with a night at Bright Angel Lodge before and after our ride. We had 2 different rooms, and both were lovely and comfortable, although we did prefer our first room, which was a bit more out of the way and had a bath (which we really could have used after our mule ride lol!). We ate at both the restaurants there and enjoyed both, although we had a bit of a wait for dinner and neither were cheap. Accommodation for the GC books out very early, so I'd recommend booking as soon as you can, especially if you're going at a peak time.
If you're planning to do something at the GC, like a mule ride or a long hike, or hire bikes and ride along the rim or something like that, I would recommend staying for 2 nights. If you're just planning to stand at the top and look at the view, 2 nights would be too much. It's beautiful and spectacular, but there's only so long you can stand there and look at it, especially for small kids.
On the way back to Vegas, we followed Route 66 for a while. It was nice to get off the freeway, but it did add a bit of time to our journey. It probably took us another 5 hours to drive back. We arrived back in Vegas around sunset, and it was super busy and chaotic to drive into. I would definitely recommend getting there early before the evening traffic hits.
You can check out my first TR (engagement trip). The GC and Vegas were our last stops and will be on the last few pages.
I have also been to Phoenix on a separate trip since then. I liked it and found it easy to negotiate on my own. I think Vegas - GC - Phoenix would be a great road trip! Check out my 10k TR for my experience around Phoenix.