What size villa have you reserved? If you have a studio or 1BR, you will most likely be in the Live Oak Lodge. The resort is mostly 2BRs.
IMHO, there are no "bad" places to be; as already stated, the resort is fairly small, so you're never far away from anything.
You either have a pool view, a marsh view, or an interior view (most of which also have a view of the harbor/marina). They are all beautiful and have their strong and not-so-strong points.
If you are in a 2BR, I would place more emphasis on whether you want to be in a first floor or second floor villa. There are about 6-8 steps to even get to the first floor. (Due to building codes everything must be elevated because of possible flooding.) The first floor is obviously more easily accessible, especially if you tend to bring a lot of "stuff" or if stairs are a challenge to anyone in your party. However, be aware that soundproofing is not the greatest at the resort (one of the very few downfalls of the resort, IMHO) and on the first floor, you often hear footsteps, etc. from the villa above.
Have a wonderful time and after you've spent some time there, you will understand why many of us say there are no bad locations at DHHIR!