Now that we finished out our bonus room, it brings our house up to 2966 square feet, just two of us, no kids or pets.
It is our first home, but we built it planning to sell within 5-6 years. We live near a good school, so I'm sure we can sell it to someone with a large family (it has 4 bedrooms, 2 1/2 bath).
I don't think it is big enough. I wish I had more closet space and a bigger kitchen/hearthroom, because when we entertain, everyone gathers there. It is really not too bad to keep neat, we mostly live downstairs... Since we have been working so much, we hired a lady that cleans where DH works to come and "really clean" every two weeks.