Where ever it is it should have good transportation to more than 1 activity, multiple parks or park and DTD. Bus transportation should not be considered. Mono-Rail or Water Taxi seem to be the best in my opinion. Home for me is BCV and I think the water taxi is great and close to 2 parks (EPCOT and MGM) was a great plus in our decision. The convenience to be able to walk to a Park and a short water taxi ride to another can't be beat.
As you may be able to tell I do not like the Bus transportation.