It takes about 4-5 hours sometimes longer depending on traffic to get down there. It also depends on where you are leaving from in Central Florida and where in the Everglades you are going to. If you are leaving from WDW property and going to Everglades National Park, which is almost the southern most area in the Everglades, it will take just over 5 hours to get there (again that depends on traffic, weather, etc).