I roll carefully and don't get any more wrinkles than when I used to fold for packing. Heavier stuff at the bottom of the suitcase, personals in a zip lock. In any case, I usually pack clothing with a synthetic blend so that they don't get very wrinkled. I hate to iron so it's really important for me to to have clothing that doesn't wrinkle much.
I generally take token gifts when I travel and after they are gone out of my bag I have room for purchases. I ALWAYS buy clothing whenever I travel so I end up wearing what I purchase.