Hi ya'll - I'm guessing you'll be on I-10 E? - Once you pass Tallahassee there's nothing until you hit I-75 S. Lake City is a nice area and there seem to be several good choices there (sorry I have not personally stayed at any of these cause we usually come through GA and stay in the Valdosta area. I would use TripAdvisor to get a good idea of what you're getting - it will certainly be an easy and quick drive from that point We DO get off at Lake City to have lunch and stretch our legs a bit!