We have done what you are suggesting, but with a bit of a wrinkle to it. We had originally booked a 2 bedroom lock off for ourselves and another couple for January. The other couple was staying for 5 nights, and we were staying for 10, so we booked the 2 bedroom lock off for 5 nights and the 1 bedroom portion for 5 nights and had them linked. Then as we got closer to the date of the trip, another couple (like family to us) was going to be in the area at the same time as the second half of our trip. We invited them to spend the 5 days on the pull out if they were amenable to that. Since they were camping, they thought it would be fine!! So, while we had two different couples and went from a 2 bedroom to a 1 bedroom, we didn't worry about the cleaning aspect of your scenario. The funny thing about all of this is that mousekeeping didn't close off the doors between the studio and 1 bedroom portion. We ended up locking them ourselves, and no one was ever put in that studio that second 5 nights. I'm not sure if they thought we still had the 2 bedroom or what, but on checkout day, the basket outside our door contained supplies for a 2 bedroom villa! It made me wish we hadn't locked that connecting door!