I could pretty much echo JimMIA, but have a couple more thoughts to add...
The heat and humidity that many mention is MUCH more of a problem in the Orlando area than it is on either coast.
Sort of. I live in Pinellas COunty on the Gulf Coast (think St. Petersburg and Clearwater) and our weather is hugely affected by Gulf temps. This means that in Spring/early summer, when the Gulf temp is still a abit lower, we tend to be a lot more comfortable then inland, like Orlando. Late summer/fall is the exact opposite; I swear you could wring moisture out of the air in Sept. Comparitively, I'm much more comfortable in Orlando that ime of year. Though the difference is negligible.

I'll also say that I weathered FL summers far better in teh first few years after I moved here from Buffalo, NY. The longer I'm down here, the worse they feel. Beats me.
Speaking of summer, one standard response I ALWAYS give to those considering a move to FL is to think very carefully about your ability to handle hurricanes and act accordingly. Could you stand to board-up and evacuate 4 times in one summer if necessary? Will you spend each summer stressed to the max if you live near water? Will you be devastated mentally and/or finacnially if most of what you own is lost to a hurricane? I lived through Hugo in Charleston, SC and I take hurricane season VERY seriously. In FL, I moved away from the water becuase I just couldn't take the stress after a summer with 5 evacs. I have a Plan, a contingency Plan and several more plans, should we ever come under threat. I encourage all FL residents to do the same.
Taxes/government services - as Jim and several others have mentioned, property taxes are undergoing some major changes right now. I work in local government and can tell you that for a very small decrease in property tax (I'm saving a whopping $65 dollars this year), my community is losing a ton of services... services that make this one of FL's most desireable areas. I have to assume plenty more areas will take similar hits. The state has GOT to come up with a better plan for paying for things, including our crappy schools.
The good news? Property values are plummeting - (okay, this isnt' good news for me, but it is for you OP!) so it's a great time to buy. Though I'll complain about the heat and humidity from June-Sept, you still couldn't pay me to swap that for a Buffalo winter. Beaches, beaches, beahces, beaches.

Really, almost endless possibilities for outdoor activities. Fantastic medical care. A booming high-tech industry base - we're moving away from being a strictly toursim-based economy to something a lot more diversified.
I do urge you to research all the different areas and find a community that fits your interests; there are SO many different options in FL!