The last time we stayed in Fort Wilderness cabins there were 6 of us with 2 people in wheelchairs. Both were able to leave the wheelchairs, so they could be folded up and out of the way. If one must stay in the chair, I expect it would be tight. Once the murphy bed is pulled down, I don't see how one could manuver very well around with the w.c. The bathroom has a roll in shower with a shower seat. I believe the toilet is elevated as well, but don't remember exactly. There is ample room in the bathroom and the kitchen area is small but still accesable. It all depends how able your grandmother is. Can she transfer? The deck is ramped of course, and there is a lot of room on the deck with a picnic table in the center.