we are very nearly in the same situation as you, and we are choosing to fly. And we are flying Delta, without a low fare deal.
We're 100 miles from Atlanta, on the Alabama side (so we do not actually go into the city-the airport comes first). Our last trip, we did the 8 hour drive, but spent the night just over the FL line, which put us driving around 5 hours on a Friday night and the last 3 on a Saturday morning. The drive was miserable, and it didn't take much to know we didn't want to do it again.
Our main reason for flying is that we are going to Disney with our dance team, and we have to be there on a Friday for them to perform. We are taking our vacation week the next week, and it was hard enough for DH and I to get that Friday off extra. Which means we'll be working Thursday before we fly out (most of the day, we'll take off about an hour early by working through our lunch.) If we were driving, we would probably end up piddling around and leave our house around 7. That puts us at Disney at 3 AM, IF we make zero stops (not happening). We won't have the option of stopping and spending the night somewhere due to DDs' dance schedule. DH wakes up for work each morning at 3:30 AM. Us arriving at Disney at 3 AM, when he's been awake for 24 hours, is not an option. He wouldn't let me drive so he can sleep. He's stubborn that way, and well, you pick your battles.
Our flight leaves Hartsfield Jackson at 8:55, so we know we have to be at the airport by 7. We'll leave our house around 5:30, at the very latest. No piddling-we're on a tight schedule. DDs can take a cat nap in the car on the way to the airport. Once we get to the airport, sure we'll have a little bit of a wait. But we can walk around, stretch our legs, have dinner. Not be crammed in car and trying to eat going down the interstate. Once we board, DH can take a cat nap on the flight. That hour or so nap will do wonders for him.
I realize that when we land in Orlando at around 10:30, we'll be pretty tired. And it might take and hour and a half to get on the bus and get to CBR. That will put us there around midnight. Is it a heck of a lot earlier than if we'd have driven? No. But for the circumstances around our trip, I think it makes a world of difference.