Depends on where you want to stay. Are you going to spend any time here, or are you just passing through? If you're just passing through, the previous poster was right about the hotels at Sav. Gateway (the intersection of I95 and Hwy. 204). There are several hotels there that are relatively new, as well as a Cracker Barrel, Perkins, Hardee's, etc. for food choices...and also a factory outlet strip mall kind of thing...If you're gonna stay a while and look around, the historic district is beautiful, and there are lots of choices there too. There is a Marriott on the river, as well as a Hyatt, and a couple of other inns that are privately owned. Also in the historic district we have a brand new Radisson, and also a Hilton, The Mulberry Inn,(which I think is owned by Holiday Inn), and several bed and breakfasts....There are lots of great restarants downtown too, including The Lady and Sons, which has become pretty well known, lots on River Street, and some chain ones like Outback Steakhouse, TGI Fridays, etc. If you want any more info, let me know!!! Have a great trip!