I've used Bonine for years (Dramamine made me very drowsy though they may have a less drowsy formula now). I am VERY prone to motion sickness so always use it an hour before a plane ride. I even used it in San Francisco this year when I rode on a small boat around Alcatraz and under the Golden Gate Bridge. I've used it for subway rides in NYC as well as car trips and it works like a dream without any drowsiness. My daughter and teenage grandson have been using it as well with great results. Take it about an hour before you travel and then later in the day if you'll be on rides, etc. all day and you should be just fine. Have a great trip!