I never mind staying at my own parents house because I always felt like I could be myself and move about the house as I pleased and that I wasn't intruding. Even with our kids, I know that if something breaks or gets dirty--it won't be the end of the world. We would still be polite and try to replace it/fix it/clean it of course---but I don't think it would be an embarrassing situation. We also have similar habits as my parents (in terms of sleeping hours, television watching, and things like air conditioning).
Most other places, I prefer hotels. I can control the temperature, I can make as much of a mess as I want, etc.