For us this is the only way to go. Staying in a hotel room for 2 or 3 weeks (the usual length of our visits) with two teenage daughters is not our idea of a vacation!
For several trips now, we have booked a home for the duration of our stay and then taken a couple of nights out to stay onsite at either WDW or USF. We book two rooms (one for us and one for our daughters) - something we couldn't possibly afford to do if we stayed onsite for the entire trip.
The homes we rent are immaculate, spacious and with their own pools and jacuzzis. The closest are 5 minutes drive from Animal Kingdom, most are within 10-20 minutes of WDW. If you'd like to know I can give you the names of the closer sub-divisions.
Fire away if you have any specific questions.