Vacations are really not vacations with young children. At least not for me. The idea of traveling anywhere alone with a toddler sounds like torture.
That being said, if you want to go and aren't afraid of the exhaustion factor of dealing with a toddler on your own, then I think it could be done. All the factors the previous poster mentioned could be overcome. There is plenty of room in a bathroom stall for two people. Heck my 7 year old still comes in with me sometimes. Riding the buses you can
rent a stroller that is very easy to fold with one hand. Handling getting food will certainly be tricky, but totally doable. So as long as you are up for the challenge, I say go for it, and don't sweat the small stuff. You'll make it work.
As for meals... I have a fairly well behaved calm kid and sit down meals have always sucked. It's just not fun trying to entertain a kid at a table for extended periods of time. And this is whether there are characters there or not. My son was 4 before he wasn't terrified of the characters, your mileage may vary as every kid is different, but I would erase any image in your mind of a nice calm relaxing sit down mea, and just know that you will spend most of the time trying to make sure your toddler isn't screaming and ruining everyone else's meal.