I have stayed in both and my preference is Portofino. Not because the room is all that much better (although the bathroom is!) so are the beds.
I like the property better at Portofino and if $ were the same would pick Portofino over a deluxe at Hard Rock. I am sure many others would pick Hard Rock. Go with your choice of theme neither is a bad choice!
Deluxe Room
Oversized, these rooms feature two Queen beds and a separate study area. Great for kicking back and grooving to your favorite downloads.
42 rooms featuring triple sheeting with duvet cover and throw pillows, an oversized reading chair, writing desk, stereo system, in-room safe, portable phone, dataport and Internet access,* coffee/tea maker with complimentary coffee and tea, custom-made cabinet minibar, bath with two sinks, hair dryer, scale, iron, ironing board, cable TV with on-demand movies and free HBO, MTV, VH1, CNN, and ESPN.
Electronic door lock featuring "Smart Room" Technology
sleeps up to five
24-hour room service
(approximate room size is 500 square feet). Look here for a 360 view.
http://themeparks.universalstudios.com/orlando/website/resort_hotels/media/HardRockDeluxeRoom.html
Portofino Deluxe Room
Deluxe Rooms
These elegantly appointed accommodations feature an even larger living space, plus a separate tub and shower in a stylish and roomy bathroom. Additional amenities include VCP (video cassette player) and surround sound system with CD player. You'll have a view of the serene Villa Pool and surrounding gardens or the dramatic Roman aqueduct styled, water slide - 490 square feet.