We normally fly from SYR, but flew from Buffalo at Christmas 2012. On that trip, we used the Days Inn Buffalo Airport for our park and fly hotel. We were more than pleased and would return in a heartbeat.
The property (rooms and common areas) were clean, clean, clean. Staff were friendly and accommodating and went out of their way to go the extra mile (bringing the little ones at breakfast colour books and crayons to keep them busy on their flight, etc.). Breakfast began super early so even those with an ungodly early flight (like us!) could grab something to eat before we left for the airport. Breakfast had a few nice surprises too, like french toast and hard boiled eggs. We expected nothing more than a muffin or bagel and coffee.
The pool and hot tub are both large and well kept. There is a great restaurant onsite that we really enjoyed (decent prices and the food was surprisingly good).
The shuttle was new, clean, and prompt. The drivers were great too....nice fellows. Location is excellent, only about 2 minutes from the front door of the airport.
And......I've saved the best for last. There's a Tim Hortons RIGHT NEXT DOOR

to the hotel. Need I say more?
If you want to see lots of pics of the room and hotel, click on my trip report here:
http://www.disboards.com/showthread.php?t=3041415
and start reading at post #6.