Since I’ve always been somewhat of a germaphobe, contents of my bag are separated into big ziplocks. It’s very efficient for security to grab the 2 or 3 ziplock bags and they can see all the contents without digging around in the dark bag. I started this on my daughter’s first visit so they weren’t digging around and touching things like burp cloths, bottles/cups, pacifiers, sunglasses, etc. I still do this even though my kids aren’t babies anymore.
This is a good option if you’re concerned about germs at security, especially since you can always wipe down the outside of the ziploc bags after security if you want.