You can, but they are a little mistake prone with this, so be sure to make a test purchase on your first day if you can and check at the concierge desk to make sure everything's getting charged to the correct KTTW card.
The only thing is I think room service and any phone charges will be charged to the primary name on the reservation.
The new computer system allows you to do it now, but as the previous poster stated, there is times when it does not work because the CM did not code the cards properly. We always test it out first.