We've stayed in 2100, 2300, and 2500. I liked 2100 the best. You could easily cut through to the Meadows area for the trading post and campfire, or hop a bus to the marina or outpost. And since that bus stop is served by both the purple and orange lines, you get a bus very fast. That helps when you're coming "home" late too.
But if you spend more time at EP, DHS, or AK, a loop closer to the entrance might work better for you.