When it is just DH and I we usually play scrabble which I love. I just got a board that spins and folds up and stores everything for Christmas. We also sometimes play blokus. I got the 4 person version last year and we loved it, but this year he bought me the version for 2 players and we have had fun playing it this week. He also got me scrabble upwords and that was pretty good as well.
If it is more than just the two of you, our favorites are probably Sequence and Apples to Apples. We do a game night once a month with two of my sisters and their husbands so there is a total of 6 adults. We play a card game called fluxx fairly often as well (fun, but not my favorite). Others that we play are phase 10, taboo and outburst.