Apples to Apples is great. We also enjoy Skip bo, phase 10, rummy. Our favorite last year was a game called Would you Rather. You get asked questions that are focused around would you rather do this or that? They are a bit off the wall and fun questions.
For the Wii you can't go wrong with Mario Kart, Disney's Guilty Party is a Wii game like Clue that's fun for the whole family, Sport Resort, the new super mario brothers (can have up to 4 players), Disney Universe looks fun (another 4 player game), the Hasbro game collection for the Wii is great as well.
Also don't forget about the old staple of dominoes. We love playing with family or friends.