Lately we've been flying, but we've driven several times on trips from MA. I always feel like one of the advantages of driving is that when it takes you two days on the road to get back, the re-entry is much more gradual and less abrupt than when you get on the plane and 3 hours later you're home.
Also as others have mentioned, we have a regularly scheduled biannual trip, so just knowing that we're coming back makes it not that bad.