While Mission Space is an incredible ride, I could never go on it again. I am claustrophobic and get panic attacks and the ride made me very dizzy and nauseous. It doesn't help that all the cast members tell you about 50 times before you get on not to look up, down, right, left or shut your eyes or you might get sick. My heart was pounding before the ride even started. For people who do not like to feel disoriented, stay away!
That all being said though, I think it is the most realistic experience for anyone who would like to be launched into space, so if you aren't bothered by dizziness or close spaces, definitely don't miss it.