Yes, I am VERY glad that I left my hometown. I left at age 18 and have never regretted it. I had a wonderful childhood and couldn't have chosen a better place to be a kid, but it wasn't a place I wanted to be an adult.
However, my disclaimer is that I can't WAIT to move back. I wouldn't do it before I was of retirement age (unless my parents needed me because they still live there) but I long for the day when I can become a part of that small town again.