I left my hometown, Mobile(AL), and DH left Pensacola(FL) when we were 22 and never looked back. We have lived in Georgia most of the last 28 years, 400 miles away from family. Best thing we ever did. When we go home for visits we find the families are still having the same conversations, the same fights, the same gossip that they were having 30 years ago. They haven't gone anywhere or done anything or read anything since we left. We've outgrown them.
I like our life here in Georgia. We travel with our kids. We read voraciously. We listen to live music and camp in the woods. Our kids were born and raised here. They have no desire to move away permanently, but if they did I'd say "go for it! Get out there and find out who you are!"
We've been told that we are selfish for not living in Florida, that we're not taking care of the family(my mom is 100% behind us, however.) My answer to that is We are taking care of the family God entrusted us with. We like our life and we like ourselves better here than there. I think, had we stayed in our hometowns, that we might have become what our families became--stifled and dull.