I think it depends on your situation. If you are using a stroller you might want to request a ground floor room. The bldgs. have elevators but only in the middle. If you are one end by the stairs you do a lot of "back tracking" to get to the escalator. That might be a consideration. If you want to be closest to the pool then you will want to request bldg. 5 or bldg 2 (I think). And, if you want a waterview of the river, I think the most centrally located bldg is bldg 5.
I agree with the other posters that POFQ is a very small resort. None of the rooms are way out there. But if you get in the outer buildings then you tend to have more privacy as there isn't as much traffic. And, many think it is much more romantic.
Also, if you don't like overhead noise then you might want to request a top floor room. Although we have seldom had a problem there was one visit where the people in the room above us wore army boots -- especially at 1am.
Personally we always request bldg. 5. But, we have stayed in bldg. 4, 5 and 6. All excellent locations.