We're flying in around the 12th Oct for a wedding-I just plan on being ready for cool and wet weather.
SFMoMA is always on my list...most of the time I scour neighborhoods for books/restaurants, so many good ones you really can't go wrong...(Castro, Mission)
But for a first visit-w/o really knowing what you're into-maybe the Exploratorium and Golden Gate Park? Check out Chinatown(I'm not into most Chinatowns but this one is a pretty good one), boat rides at Pier 39, Haight Street, Sharon Meadow (aka hippie hill)...
If you MUST-I suppose a trolley-or wait, they might not like you calling it that-or was it 'streetcar' that they don't like...
enjoy, it's a nice, mellow town!
ohyeah-Disney fans, of course-don't forget the original Ghirardelli's at Ghirardelli Square!