Good and bad news: The good news is that the housing market is decent in the central coast area - if you're willing to look in the general vicinity of Vero...including south and north a bit, the houses are significantly less expensive than South Florida and Central Florida. Taxes aren't too high, but insurance stinks (hurricanes!). No state taxes either which is nice. Pretty area - lots of nature around, with the beaches, intercoastals, rivers, wetlands areas, etc.
The bad news is that the job market is a bit depressed. It's not as bad as in some parts of the country, but it's not great. If you've got a professional degree, you've got a chance of sliding into your specialty, but if you're just on the hunt, there's not a lot open. South Florida is slightly more open job-wise - still not great, but better than much of the nation. Central coast Florida was in a boom for the past decade (especially Port St. Lucie), and once the economy turned, the housing market crashed hard in the real estate bust, jobs slowed, less people moved in, less big companies relocated up there to offer new jobs, and the area is not a large industrial or corporate complex - the entire area is really more a series of towns than an actual city, so it doesn't tend to have the infrastructure that large metropolitan areas do.
If you keep your sights broad, and are willing to search within a 60 mile perimeter of Vero area, it will give you other town clusters to enlarge your job hunt area, and give you a better chance. There are a surprising number of people who commute in and out of as far south as Palm Beach and as far north as Daytona...with the population still not too out of control, highways rarely suffer heavy traffic unless there's an accident, so you can jump on the freeway for a 70-80mph commute and be there in under an hour. Palm Beach is relatively close too, so you might consider hunting around as far south as Boynton Beach/Delray Beach, which still puts you only an hour and change from your friends or family if they choose to live in the Treasure Coast area. It's all pretty connected - I'm all the way south in Boca Raton, yet my local news channels out of Palm Beach cover from my city all the way to Vero for local news.
That's about as much as I know about it - I'm fortunately not on a hunt for jobs, and have lived here for quite a while, before the boom hit farther north. But we get a feel for it on the local news, with more of the job problems, unemployment, housing woes (many foreclosures and tons of available houses which is killing the real estate market - good news for newcomers) up north in the Treasure Coast area.
Hope that helps!