We live in New England and have enjoyed the Equinox, Juniper Hill, Sagamore and Windham Hill. First of all, late in October would not be my choice of time of year to visit New England. I would recommend the first or second week of Oct. when fall is basically at its peak. The Equinox and Sagamore are larger and more hotel like. Both are top shelf, located in beautiful country, outlet shopping and area attractions see their web sites. You might fly into Albany NY airport.
Juniper and Windham Hill are true Bed and Breakfasts. Both are near lots of local attractions (Vermont stuff), feature romantic rooms with fireplaces, excellent homey dining and are basically adult only places. Again the nearest airport might be Albany or perhaps Manchester, NH. In any case, all four places are top quality and recommended. All have web sites check them out. You and your wife would have a very enjoyable stay in any case.