Driving in LA is not a big deal IMO. It's busy, and the 6 lanes of traffic in each direction can be extremely intimidating, but it's all highway driving and pretty straight forward. Nothing like driving in cities like Toronto or Boston. The biggest thing I think people have a problem with is the u-turns- no other cities seem to embrace them like LA. But there are lanes dedicated for u-turns so it's really easy. As long as you're prepared to have to force yourself in when there's heavy traffic, you'll be fine.