1st it will depend on how economical you want to get.
Then it will depend on which parks are most important to you and your family.
That being said, if you don't mind spending the money, I would suggest staying at the Polynesian on the monorail. Since you stayed at an Epcot resort last time, staying at an MK one would be a great change of pace.
If you want to be a little more economical, then I would suggest CBR. The kids will love the warm sandy beaches with the hammocks and playground equipment. Also, the way the pool is set up, it is very easy to keep an eye on your little one. They also have the best quiet pools around. I would recommend staying in Martinque for the convenience of being near the food court and main pool. Bldg 25 is very nice!
If economy is your main equation this time, might I suggest the AS- Movies, perhaps the Toy Story building or maybe the 101 Dalmation building which are preferred buildings and next to the food court and bus stop. The kids will love the theming and huge icons.
Whatever you decide, you really can't go wrong in a Disney Resort!