I would still watch. I'm not a huge fan but the one liners have always been hilarious which means the writers are the geniuses, not Charlie. I don't think it would be too hard to replace Bi-winning, isn't Hollywood full of aging Peter Pan's who can't get a grip? All they'd have to do is drive-by the Playboy Mansion and see what drags itself out of there, put him in a bowling shirt and an IV of penicillin and we're off again.
OK, that was kind of mean... not exactly untrue but sort of mean anyway.
BTW, I think different people laughed at different things. When I watch the show I was never laughing WITH Charlie & his antics, I was laughing AT his ridiculous character because I have met guys who are like this. The cheesiness totally cracks me up.