We are flying down for the weekend of 10/16-10/20 specifically to do Food and Wine while leaving our DD at home.
My opinion is there are many, many ways to do food and wine, as there is much to do. There are just the booths, then there are all the extra events you could possibly sign up for. (Party for the Senses...etc.) I'll ignore those for now, purely for the food and wine aspect of it, here is how we plan on doing it:
We are going to allow two days, and we are basically going to split WS in half. We'll go Friday and Sunday, and will use the Food and Wine booths for our lunch/dinner. Particularly on Friday we will probably wrap up the F&W portion early enough to avoid the worst crowds, and head over to Jellyrolls for the evening. Sunday we may do something similar, or stay for Illuminations.
Alternately, you could do it where you go every day with hoppers and only eat a few things. Or you could go there in the evenings just for a drink.
If you are smart, you would plan to do it on Monday - Thursday. We can't because we are just flying down for the weekend, but that is the way I would do it. In fact, Epcot on Thursdays during F&W in my experience is the absolute emptiest you will even see that park. (Well, maybe January.)
Understand that while the prices aren't bad, the spending adds up very quickly. If you are going for the day, expect to spend $100+ per person, unless you drink heavily and then it will be much more.