Were I the one making the decisions (and I'm sure there's a good amount of people who are glad I'm not!!!

) I definitely wouldn't replace Disney Quest. I think they need to be really careful about soemthing like this.
I really like Dave and Busters, but something like Disney Quest is unique. If people can do something at home, chances are, they may not want to do it on their vacation, especially if it is a short vacation and they are trying to cram as much in as possible. I have a Dave and Busters at home, therefore, I'd rather do something at WDW that I CAN'T do at home.
Just my .02
On the topic though, it is kind of sad to see that Virgin Megastores are closing everywhere. I didn't really go there a lot, but it's still sad.