For kids in diapers, don't forget to pack jammies and night time diapers/Pull Ups in your carry on bag, just in case the ME luggage takes its sweet time to arrive!
When we travel, DH carries the laptop, camera, chargers, cell phones, Ipod, book, change of clothes, etc. We use the laptop on the plane to let the girls watch a movie.
The girls will each have their own backpack on wheels. They will take one favorite dolly, Leapster + games, Gloldfish snacks, small playthings, a change of clothes for once we arrive, esp if we are going from a cold to warm climate or vice versa.
I get everthing else. Yes, I am a pack mule.
Diapers/wipes to last a while, just in case! Extra undies for the girls and me, change of clothes for me, book or magazine (but I usually can't read anything!), stickers, lollipops an gum for plugged ears, some new small toys that we've never seen before, meds, Epi Pens and chewable Benadryl (DD has a peanut allergy), extra snacks, empty sippy cups (will try to get apple juice through security - I think that's acceptable), my make up, hairbrush, etc. I'm sure there is more!