We were there last week, and while I am by no means a FP+ expert, this is what we did:
1. Book as many FP+ online beforehand as possible.
2. In cases where both attractions we wanted were in the same tier (I hate that system, by the way), we chose the FP for the one that did NOT have a single rider line. For example, both Rock n Rolllercoaster and Toy Story Mania are in the same tier for HS, but RnR has a single rider line, TSM does not. So we had FP+ for TSM and did single rider line for RnR.
3. Bring your smartphone with you in the park. You can check wait times and adjust your FP+ if needed.
That's all I can think of for now. Good luck!