Hi Marsha,
Probably, I too would forget the first one. What if you have a problem throughout the process, have questions, and during rental, you won't be able to afford to wait this long for a reply. This is a very bad sign.
Number 2, today is 3 days since you e-mailed? Still, not a good sign. But if you want to call just to get a feeling for them, interview them in a sense, just have a little list of questions about the rental, open ended to see what their responses are. Mention to them that you e-mailed them several days ago, etc. Then make a decision if this is someone you want to put trust in for your vacation experience. Trust is very important, both ways, as you are trusting them for your valued vacation experience and they are trusting you with their expensive vacation home.
Keep looking as well. There are lots of nice places out there and owners that will get right back to you no matter what!
Sandy