As of March 30, 2008, there are 399 Tim Hortons locations in the United States. These are primarily situated in (and the areas surrounding) Buffalo, Rochester (New York), Detroit, Flint, Saginaw, Bay City, Midland, Lansing(Michigan), Columbus, Dayton, Toledo (Ohio), Erie (Pennsylvania), Charleston, Huntington, Wheeling (West Virginia), Maine, Rhode Island and Connecticut.(just as an FYI)
If driving I-77or I-79 & I-95 you will have Sheetz in Pennsylvania,West Verginia, and North Carolina,They have Hot and Cold Subs,Deli Sandwiches,wraps, there web site is Sheetz.com they have a full menu on there.Alos In Pennsylvania there are country fair's if you like strong coffee this is where to go they will also make subs and have good pizza. The Flying J, TA truck stops and the Pilot all have good coffee and most have fast food places in them.
If driving I-75 the last timmys that i know of is in Monroe, OH exit 29 then you will have your dunkin donuts and your truck stops.

We are driving down to DL and wondering if there is any place you could recommend for a quick soup and sandwich/ wrap place like Tim's. THX
Although the coffee is different, it is pretty good. We like to stop at Panera Bread anywhere in the US. They have great sandwiches and soups at reasonable prices. Did a quick check on their site, and there are many locations down the left coast.

There are a couple of locations in Canada now! We have tried the one at Square One Mall in Mississauga and it is wonderful! We always frequent the Panera Bread in the Loop Mall in Orlando as well when we are down visiting Mickey!
I guess I'm odd, I don't need my caffeine fix in the morning, I wake up feeling pretty good. I need a coffee in the afternoon. So that's where the bottle of caffeine pills helps, on the days when I just can't find coffee. BTW, I found it very hard to find an afternoon coffee in WDW, and when I did find it, it was usually overpriced and pretty crappy. So I almost always use the caffeine pills at WDW.