Well I will offer my advice having done a nearly 1,000 mile drive as the solo driver (DW was in the car but I did all the miles behind the wheel).
My drive was in January which meant shorter daylight times so we left about 2-3 hours before sunrise, drove all day in daylight, and got to our destination about 2-3 hours after sunset. For me, personally, I have no problem being awake and driving early. But after the sun sets, I get more tired so I probably would never drive more than 3 hours past sun set (which in my travel direction was VERY familiar territory, I knew every crack in the interstate pavement, and could manage easily to get home). Our entire drive was all interstate (besides the <3 miles on either end).
But depending on weather conditions and time of day/travel, you might encounter an accident/traffic backup. So I would recommend a back-up plan or pick a stop or two along hte way in case you run into delays that (I know you said you don't want to) but places you have pre-screened for an early- or late-stop along the way. I think of the folks coming down I95 and there can be traffic issues (not my route).
I can vouch for 'start early, drive all during sunlight with few stops, and only go 2-3 hours after dark' but be prepared for the unexpected. God bless you and good luck with your decision.
Bama Ed