WE would skip HS if we had 3 days.
While it has thrill rides, cupcakes and TSM, we love the other parks more.
In four days, with the requirement of 2 days at MK, we would hit AK for the early part of the day and HS the same evening. The only thing you will probably miss out on is TSM.
Some people may do AK during day and evening at Epcot.
It depends on so many factors. Is this the only trip ever to WDW? What ages are the park goers? Do you like thrill rides or shows? No right or wrong way - just do what works for you and yours.
I am assuming the Posters question is hypothetical, since they have been there before.