After spending the first 20 or so years of my life not even knowing I had sinuses, I've had quite a few sinus infections over the last 18 years. As I get older, they seem to be getting worse. Mine starts with an INCREDIBLE headache, then the toothpain others have posted about. I have tried different things in an effort not to depend too heavily on antibiotics, and this is what is working right now: the Walmart brand(Equate) SEVERE allergy and sinus, and Mucinex. The key seems to be to start this regiment as soon as I get the headache. If I take Zyrtec regularly during certain months, it seems to head off the sinus trouble, but if I forget...it will most certainly end up a near-death experience for me.