We have done the drive down to WDW many, MANY times (been doing this ride since 1975) and we always stay in Santee, SC. Our favorite is the Ramada Inn. It is very nice, clean, and reasonable (about $50 per night) but make your reservations ASAP!!! This hotel is a favorite of golfers that frequent the area and it fills up fast. If the Ramada is booked then try the Days Inn next door. It is also clean and Very reasonable.
Have a great trip!