Even if you think you won't be using tranqs get some anyways, from a trusted vet, ahead of time. You do not want to be looking for a vet in an unknown town.
When I moved, my kitty was too small to take on a plane, so we
had to go by car. The first day, she cried & yowled the whole 10-1/2 hour drive.

The second day she yowled for another 5 hours before I finally pulled off to a quiet service road.
I just about had it with her with the noise. I really didn't think she would yowl for that long. I could not take it for another few days. On the shoulder of the service road, I let her out of the carrier, and let her roam around inside the car, thinking, if she got used to her surroundings, before putting her back in, it would calm her down.
No dice, as soon as she was put back in the carrier, she started yowling again. It got so bad, I alternated between dropping her off at the pound, (knowing I'd regret it once the trip was over with.) Stopping at an unknown vet for drugs, but fearing it may hurt the cat, (because I truly loved her dearly.)
But one other idea came to me. I let her back out again. While she was sitting up on the dashboard, I slowly pulled forward, on the empty service road, at about 5 miles an hour. She simply looked around like she was watching tv! I drove a little faster, until she got used to that. Finally we were back on the open freeway at full speed. She just hunkered down & watched out the window without a sound!!! Whew!
When she finally got bored with that, she came over and crawled up into a ball in my lap & slept most of the rest of trip like that. I had her kitty litter box out, in case she needed it. And put out water for her.