I like Hotwire- here's how it works.
You enter your dates of travel and city you are staying in. A list of available hotels comes up- you can fine tune the locations within the city you need at that time. The price per night, hotel area, star rating, amenities offered, and other general information will be available- the one thing you WON'T know until you book is the name of the actual hotel (bookings are non-refundable, btw).
I have had really good luck with Hotwire- give them a try! Just make sure you match up the star rating, area, and amenities before you book, so you will get approx. what you expect.
Priceline is pretty much the same, EXCEPT you bid on the price. Say you want a 3 star hotel in LBV with a hot breakfast. You bid the price you'd be willing to pay, and Priceline "shops" their inventory. If a hotel accepts that price, you win the bid, and at that point, you are booked with a non-refundable reservation. At that time, you will find out the name of the hotel. If none of the hotels will take that $$ amt, you will be told to change either your bid price or the star rating. I don't like this system as much- it takes longer and I have had experiences of having to pay a bit more for the same quality hotels compared to Hotwire.
Hope that helps a bit- good luck with trying out either site!!