Not at all. I carry two 7 day pill boxes every trip. In one I have my prescription meds for the week. In the other I have each slot filled with an OTC med (Motrin, antibiotics, Pepto, etc). I've never had them even questioned.
In fact, just a few days before we left on our vacation this past October, my doctor decided to pt me on the Victoza pen for my diabetes. Rather than write me a prescription for it she gave me a sample pen. I was concerned abut getting through security with it, since it didn't have a prescription on it, used double ended needles, and needed to be kept cold. I voiced my concerns to my doctor and she laughed saying she traveled with them herself, never had a problem, and that the TSA was there to look for items that might endanger other flyers, not for drug control. She was right. I placed the Victoza pen with it's needles in an insulated lunch bag with two of those little frozen thingys and put my glucometer with it's lancets in an outside pocket. Before going through security I placed the pen, needles, and frozen ice things on top of the insulated bag. Neither they, nor the pill boxes inside my carryon even got a second glance.
My mom also travels with all her meds in pill boxes and with insulin and insulin syringes every time she flys. They've never been questioned.