we had 3 in my DHs hyundai, but it was a tight squeeze. I drive a durango and it is huge, plenty of room. BUT I never had 2 infants at one time in it, and you have to move one of the middle seats to get to the back seat, so if I were you I'd go with a minivan for convenience, (sp?) My fave minivan is the Dodge Caravan, I like the spinning seats. But next I like the Toyota for the stow and go seating. Congrats on your twins.