I think it depends on the company and the job you're interviewing for. For example, if it's a technology company and you're a computer programmer, you could ask about the vision of the company and where the big boss sees people with your skills headed. If it's a retail company, you might ask instead what changes they foresee in light of the current economy. For any company, you could ask about the "green" aspects of the company and its impact on the environment. You might also want to explore how the company interacts with the community in which it resides. I liked what the previous reply said, and I also second that you must research the company and be knowledgeable about it. Good luck!
-Dorothy (LadyZolt)