Ah....okay. I thought you were coming from the airport.
So, assuming you are taking the turnpike all the way to I-4, you'll be heading west on I-4 about 1 or 2 exits to get to Kirkman. Typically, the traffic heading westbound is really ugly around downtown (which will be east of where you'll get on the highway) and then it tends to bunch up again when you get closer to the the Disney exits (west of where you'll be going). Unless there is an accident, you really shouldn't hit any back-ups. And if you do, you don't have far to travel so it shouldn't be too long of a wait.
Good luck with the drive and have an awesome holiday!